![]() ![]() Interaction of citrus juices with felodipine and nifedipine. Cancer Research 41: 67–72, 1981Ĭhayen R, Rosenthal T. Activation and inhibition of benzo(a)pyrene and aflatoxin B-1 metabolism in human liver microsomes by naturally occurring flavonoids. ![]() 4): S60–S64, 1990īuening MK, Chang RL, Huang MT, Fortner JG, Wood AW, et al. Journal of Cardiovascular Pharmacology 15 (Suppl. Optimal felodipine dose when combined with metoprolol in arterial hypertension: a Swedish multicentre study with primary health care. Journal of Cardiovascular Pharmacology 15: 428–435, 1990īrun J, Froberg L, Kronmann P, Olsson LB, Skoog P, et al. Plasma-concentration effect relationships of intravenous and extended release oral felodipine in hypertensive patients. British Journal of Clinical Pharmacology 31: 15–24, 1991īlychert E, Hedner T, Dahlof C, Elmfeldt D. A population study of the pharmacokinetics of felodipine. Lancet 337: 268–269, 1991īlychert E, Edgar B, Elmfeldt D, Hedner T. Clinical and Investigative Medicine 12: 357–362, 1989īailey DG, Spence JD, Munoz C, Arnold JMO. Ethanol enhances the hemodynamic effects of felodipine. Clinical Pharmacology and Therapeutics 51: 156, 1992īailey DG, Spence JD, Edgar B, Bayliff CD, Arnold JMO. Grapefruit juice and naringin interaction with nitrendipine. Clinical Pharmacology and Therapeutics 55: in press, 1994īailey DG, Munoz C, Arnold JMO, Strong HA, Spence JD. Marked effects of both erythromycin and grapefruit juice on felodipine pharmacokinetics. Clinical Pharmacology and Therapeutics 54: 589–594, 1993bīailey DG, Arnold JMO, Tran LT, Ahktar J, Spence JD. Effect of grapefruit juice and naringin on nisoldipine pharmacokinetics. Clinical Pharmacology and Therapeutics 53: 637–642, 1993aīailey DG, Arnold JMO, Strong HA, Munoz C, Spence JD. Grapefruit juice-felodipine interaction: mechanism, predictability and effect of naringin. Clinical Pharmacokinetics 15: 1–14, 1988īailey DG, Arnold JMO, Munoz C, Spence JD. Pharmacokinetics of calcium antagonists under development. It seems that this discovery has provided fundamental new knowledge both to improve pharmacotherapy and to stimulate further research.Ībernethy DR, Schwartz JB. Furthermore, it may lead to exploitation of the inhibitory effects of the active ingredient(s), and its inclusion into drug formulations to increase the clinical efficacy of orally administered drugs. ![]() Identification of the active ingredient in grapefruit juice may allow the prediction of other foods that may also interact with dihydropyridines and some other drugs. ![]() Since current information indicates that the interaction is variable and unpredictable, it appears reasonable to caution patients not to ingest grapefruit juice at the same time as taking felodipine and other dihydropyridines. The clinical relevance of the grapefruit juice interaction with each particular drug will depend on the magnitude of change in the pharmacokinetic profile of the drug, the drug concentration-response relationships and the patient. The serendipitous finding that grapefruit juice interacts with felodipine was subsequently found to be valid for some other dihydropyridines, but this interaction is probably not limited to this class of drugs. ![]()
0 Comments
Leave a Reply. |